Figure 6
Genomic analysis of a linear plasmid carrying vanA (pIHVA). (a) Genomic structure of pIHVA from the Hb35 strain. Block arrows indicate confirmed or putative open reading frames (ORFs) and their orientations. Arrow size is proportional to the predicted ORF length. Color code is as follows: red, antimicrobial resistance genes; orange, transposase genes; green, plasmid replication initiator genes; light green, resolvase genes; cyan, genes encoding proteins of known function; deep blue, insertion sequence; and magenta, plasmid stabilization system. Putative, hypothetical, and unknown genes are represented by gray arrows. (b) Comparison of Tn1546-like region of pIHVA-Hb35 with its prototypical structure from BM4147. (c) Types of pIHVA found among 50 representative VRE isolates. aRegion deletion of 123 bp. bRegion deletion of 971 bp. cRegion deletion of 1400 bp. dRegion deletion of 1416 bp. eRegion deletion of 292 bp. fRegion deletion of 1380 bp. gRegion deletion of 944 bp. hInsertion of ISEnfa3 within ISEfa11., iRegion deletion of 1721 bp.
