Figure 3

Tetraploid cells exhibit increased rates of chromosomal instability. (A) Chromosome counts in sorted diploid and tetraploid cells from the spontaneous model. Bars indicate the median cell count. Differences in variance between diploid and tetraploid cells was determined using an F-test for variance, p = 0.0073. (B) Chromosome counts in sorted diploid and tetraploid cells from the induced model. Bars indicate the median cell count. Differences in variance between diploid and tetraploid cells was determined using an F-test for variance, p < 0.0001. (C) Chromosome counts in single-cell clones derived from diploid or tetraploid cells from the spontaneous model (n = 35). (D) Chromosome counts in single-cell clones derived from diploid or tetraploid cells from the induced model (n = 25). (A–D) were generated using Graph Pad Prism 9 software (version 9.0.0 (86) for Mac, https://www.graphpad.com/scientific-software/prism/).