Figure 4

Polyploid recurrent tumors exhibit a growth defect relative to diploid tumors. (A) Kaplan–Meier plot showing tumor-free survival for mice injected with diploid or polyploid tumor cells from the spontaneous model. Hazards ratio (HR) and p value were determined using a log-rank test. (B) Tumor growth curves for diploid and polyploid tumors from the spontaneous model. (C) Mean growth rate for diploid and polyploid tumors from the spontaneous model. Significance was determined using Welch’s t-test. (D) Kaplan–Meier plot showing tumor-free survival for mice injected with diploid or polyploid tumor cells from the induced model. Hazards Ratio (HR) and p-value were determined using a log-rank test. (E) Tumor growth curves for diploid and polyploid tumors from the induced model. (F) Mean growth rate for diploid and polyploid tumors from the spontaneous model. Significance was determined using Welch’s t-test. (A–F) were generated using Graph Pad Prism 9 software (version 9.0.0 (86) for Mac, https://www.graphpad.com/scientific-software/prism/).