Table 2 Rates of positive BRCA1 and BRCA2 mutations; subgroup analysis.
Variable | Total | Positive Mutations | ||||
|---|---|---|---|---|---|---|
BRCA1 | BRCA2 | BRCA1& BRCA2 | P-Value* | |||
Age at diagnosis (years) | ≤ 35 | 341 | 16 | 34 | 50 (14.7%) | 0.017 |
> 35 | 275 | 9 | 16 | 25 (9.1%) | ||
One or more close relative with breast cancer at any age | Yes | 305 | 9 | 37 | 46 (15.1%) | 0.029 |
No | 311 | 15 | 14 | 29 (9.3%) | ||
One or more close relatives with breast cancer diagnosed at age 50 years or younger | Yes | 153 | 3 | 24 | 27 (17.6%) | 0.017 |
No | 463 | 22 | 26 | 48 (10.4%) | ||
Diagnosed at ≤ 60 years with triple negative disease | Yes | 69 | 16 | 7 | 23 (33.3%) | < 0.001 |
No | 547 | 9 | 43 | 52 (9.5%) | ||
Any age with at least 2 breast cancer primaries | Yes | 48 | 6 | 8 | 14 (29.2%) | < 0.001 |
No | 568 | 19 | 42 | 61 (10.7%) | ||
Two or more close relatives with breast cancer | Yes | 97 | 5 | 24 | 29 (30.0%) | < 0.001 |
No | 519 | 20 | 26 | 46 (8.9%) | ||
All patients | 616 | 25 | 50 | 75 (12.2%) | ||
