Figure 1
Alterations in the proteome of monocytes in the acute phase of sepsis (Sepsis group), compared with the recovery phase (Recovery group) and healthy subjects (Control group). (a) Total, unique, and shared protein identifications among the experimental groups. (b) Molecular degree of perturbation of the Sepsis end Recovery groups in relation to the Control group. The plot represents individual values with median and IQR per group. (c) Volcano plot of all shared proteins in the comparisons between the Sepsis and Control and Sepsis and Recovery groups. Each dot represents a protein mapped according to its log2 (fold change) on the y-axis and its − log2 (t-test p value) on the x-axis. The red dots indicate proteins that satisfy neither the fold-change cutoff nor the p value (0.05). Green dots depict protein entries that meet the fold-change cutoff but not the p value. Orange dots indicate proteins that satisfy both fold-change and p value but have low abundances, as determined by an additional stringency filter. Blue dots represent protein entries that met all statistical filters and were selected for further analysis. (d) Total and shared proteins significantly up (red bars) or down (blue bars)-regulated in the comparisons between the Sepsis and Control and Sepsis and Recovery groups.
