Table 1 Demographic and clinical characteristics according to the presence or absence of HCC in cirrhotic patients.

From: Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

 

Cirrhosis without HCC n = 161

Cirrhosis with HCC n = 130

P value

Age (years)

55.00 (49.10–60.04)

58.10 (51.67–62.80)

0.001

Gender M (%)

127 (78.9)

110 (84.6)

0.272

BMI (kg/m2)

25.34 (23.52–28.43)

26.67 (23.88—30.03)

0.027

Diabetes, yes, n (%)

41 (25.5)

38 (29.2)

0.473

Etiology of liver cirrhosis, n (%)

0.033

HCV

36 (22.4)

39 (30.0)

 

HBV

10 (6.2)

9 (6.9)

 

Alcohol

58 (36.0)

31 (23.8)

 

Virus + alcohol

24 (14.9)

31 (23.8)

 

Post-NASH

15 (9.3)

14 (10.8)

 

Others (cholestatic, Wilson etc.)

18 (11.2)

6 (4.6)

 

Ascites, yes (%)

97 (60.2)

50 (38.5)

 < 0.001

Furosemide, yes (%)

105 (65.2)

61 (46.9)

0.003

Potassium-sparing diuretics, yes (%)

117 (72.7)

74 (56.9)

0.007

Nonabsorbable disaccharides, yes (%)

76 (47.2)

51 (39.2)

0.213

Levothyroxine, yes (%)

8 (5.0)

7 (5.4)

0.873

Proton pump inhibitors, yes (%)

92 (57.1)

72 (55.4)

0.856

MELD score

15.00 (12.00–19.00)

14.00 (11.00–17.00)

 < 0.001

Serum Mg (mg/dl)

1.90 (1.72–2.08)

1.80 (1.62–1.90)

 < 0.001

Hypomagnesemia, yes (%)

24 (14.9)

37 (28.5)

0.007

Serum Ca (mg/dl)

8.69 (± 0.61)

8.74 (± 0.67)

0.587

Mg in diet, mg*

93.20 (75.06–119.97)

93.03 (71.87–129.30)

0.990

Ca in diet, mg*

699.56 (± 258.49)

699.68 (± 274.60)

0.998

  1. Continuous variables are shown as median and interquartile range or mean ± SD, according to the absence or presence of normal distribution. Categorical variables are shown as numbers and percentages. The characteristics refer to the time of blood sampling to determine the concentration of Mg, corresponding to the first visit for patients without HCC and to the time of diagnosis of HCC for patients with cancer.
  2. BMI body mass index, Ca calcium, HBV hepatitis B virus, HCC hepatocellular carcinoma, HCV hepatitis C virus, MELD model for end-stage liver disease, Mg magnesium, NASH non-alcoholic steatohepatistis.
  3. *Available only in 52 cirrhotic without HCC and 39 cirrhotic with HCC. p-values numbers marked in bold indicate numbers that are significant at the p < 0.05 level