Figure 7
Renal sympathetic denervation worsened renal fibrosis after IR in TAC mice (Experiment 3). (A) Fractional Norepinephrine (NoE) turnover rate (%/h), (B) NoE concentration in kidney (ng/g kidney), (C) Quantified renal fibrotic areas and (D) α-SMA positive area, and (E) mRNA level of TGF-β are shown (n = 5–7 per group). #p < 0.05. In (B), open triangle represents non-TAC mice without RSDN and IR; gray triangle non-TAC + IR mice without RSDN; filled triangle non-TAC + IR with RSDN; open circle, TAC mice without IR and RSDN; gray circle, TAC + IR mice without RSDN; filled circle, TAC + IR + RSDN mice. In (C–E), open triangle represents non-TAC + IR mice without RSDN; filled triangle non-TAC + IR with RSDN; open circle, TAC + IR mice without RSDN; filled circle, TAC + IR + RSDN mice. All graphs were created using JMP 14.0 software (SAS Institute Inc., Cary, NC).
