Figure 3

mTOR and JNK phosphorylation is increased with exercise duration, and for JNK also in a load-dependent manner. Specific phosphorylation of Y397-FAK (a), pS2448-mTOR (b) and pT183/Y185-JNK (c) shown as fold change in exercised relative to their respective contralateral control TA muscles after 2, 10 and 28 min of exercise with a high or a low load. Post-hoc significant differences denoted with *,** p < 0.05 and 0.01 versus control leg; + ,  ++ p < 0.05 and 0.01 versus 28 min exercise within loading groups; $$ p < 0.01 versus low load exercised group after 28 min of exercise. Data are presented as individual muscle values (circles) and group means with 95% CI (n = 8 per group for the 2 min and 28 min protocol, n = 9 per group for the 10 min protocol). Dotted line at y = 1 representing no difference between exercised leg and contralateral control leg.