Table 1 Three-way ANOVA for the factors exercise, load and muscle type (corresponding to Figs. 1 and 2), or exercise, load and exercise duration (corresponding to Figs. 3 and 4), showing percent of total variation and corresponding p-value for the respective factors and interactions.

From: JNK activation in TA and EDL muscle is load-dependent in rats receiving identical excitation patterns

Figure 1

p-FAK

p-mTOR

p-p70S6K

p-JNK

Source of variation

%

P value

%

P value

%

P value

%

P value

Load

0.556

0.4259

0.5599

0.2334

1.321

0.0094

10.82

0.0016

Muscle

2.355

0.5644

50.33

< 0.0001

5.15

0.0154

2.055

0.1333

Exercise

0.0686

0.8325

33.62

< 0.0001

58.32

< 0.0001

39.85

0.0001

Load × muscle

0.0686

0.7769

0.1308

0.528

0.444

0.471

0.00001881

0.9959

Load × exercise

0.2809

0.5213

1.013

0.0249

1.398

0.0041

10.64

0.0015

Muscle × exercise

0.208

0.511

1.009

0.0227

3.289

0.0192

1.075

0.2722

Load × muscle × exercise

0.003427

0.9639

0.0448

0.4715

0.2354

0.5938

0.002939

0.9467

Figure 2

FAK

mTOR

p70S6K

JNK

Source of variation

%

P value

%

P value

%

P value

%

P value

Load

0.07586

0.5918

0.0011

0.9107

0.0002

0.9746

0.6114

0.0282

Muscle

60.22

0.0015

95.81

<  0.0001

87

<  0.0001

66.89

0.0004

Exercise

0.7377

0.2619

0.1215

0.1679

3.463

<  0.0001

3.744

0.0323

Load × muscle

0.01537

0.8323

0.0875

0.3562

0.1765

0.3254

0.9

0.0277

Load × exercise

0.4963

0.0956

0.0311

0.4017

0.0129

0.7796

1.483

0.0154

Muscle × exercise

1.093

0.0286

0.0572

0.306

1.449

0.0058

0.4823

0.283

Load × muscle × exercise

0.2397

0.4947

0.0399

0.3746

0.0112

0.7859

0.003449

0.8932

Figure 3

p-FAK

p-mTOR

p-JNK

  

Source of variation

%

P value

%

P value

%

P value

  

Duration

2.946

0.4101

30.66

 < 0.0001

20.39

 < 0.0001

  

Load

1.03

0.1746

6.028

0.0045

3.367

0.0022

  

Exercise

0.4182

0.5661

29.12

 < 0.0001

25.87

 < 0.0001

  

Duration × load

0.0264

0.9714

2.134

0.1577

4.707

0.0022

  

Duration × exercise

1.462

0.1197

2.253

0.0003

18.73

 < 0.0001

  

Load × exercise

0.006945

0.9117

0.01774

0.7578

2.999

0.0023

  

Duration × load × exercise

0.116

0.9316

0.5369

0.1928

4.647

0.0006

  

Figure 3

FAK

mTOR

JNK

  

Source of variation

%

P value

%

P value

%

P value

  

Duration

41.37

0.0014

10.92

0.0634

25.56

0.0008

  

Load

0.02836

0.857

1.044

0.4124

2.487

0.0875

  

Exercise

0.6267

0.068

1.644

0.0595

0.093

0.5708

  

Duration × load

0.04421

0.9728

2.138

0.1661

1.012

0.5435

  

Duration × exercise

0.4248

0.3948

1.335

0.4997

1.916

0.2522

  

Load × exercise

0.1771

0.3908

0.1599

0.3419

0.7331

0.2183

  

Duration × load × exercise

0.1934

0.7647

0.4274

0.7462

0.2533

0.6828

  
  1. P values < 0.05 highlighted in bold.
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