Table 3 ROC analysis parameters of pathological cIMT (A) and prior CVD (B) logistic models.

From: Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

 

AUC

Cut-off

Sensitivity

Specificity

PPV

NPV

P

A. Pat-cIMT

Model 1

0.8

0.21

0.85

0.67

0.47

0.93

 

Model 1 + miR-451

0.83

0.19

0.91

0.7

0.51

0.96

0.027

Model 2

0.85

0.26

0.89

0.81

0.62

0.96

 

Model 2 + miR-425-5p

0.87

0.24

0.83

0.89

0.64

0.96

0.036

B. Prior CVD

Model 3

0.91

0.16

0.93

0.78

0.5

0.98

 

Model 3 + miR-425-5p

0.93

0.35

0.97

0.79

0.85

0.95

0.008

  1. ROC analyses were performed by logistic regression analysis applied to women (model 1) and to men (model 2 and 3) with or without inclusion of candidate miRs expression. Models were initially adjusted for age, RA disease onset, BMI, ischemic heart disease, peripheral artery disease, ictus, creatinine, and treatments. P values were obtain from the Likelihood Ratio test. AUC = area under the curve. PPV = positive predicted value. NPV = negative predicted value. P = p value.
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