Figure 4
The role of ICaL alternans in ignition of CaT alternans. ICaL were evoked by 3 subsequently applied alternating voltage clamp pulses, having a basic cycle length of 220 ms in all cases (a). (b) Illustrates a membrane current and CaT measurement evoked by a 140/80 ms voltage protocol. The ICaL peaks as well as the corresponding CaT did not show notable alternans. (c) Represents alternating ICaL and CaT during application of 180/40 ms protocol. (d) Illustrates a close relationship when the peak ICaL alternans were plotted against the corresponding CaT amplitude alternans. The black circles represent experiments evoked by 140/180 ms protocol, the blue circles demonstrate measurements under 180/40 ms protocol, while red circles indicates recordings during 200/20 protocol.
