Figure 1
From: Urine peptidome analysis in cardiorenal syndrome reflects molecular processes
Urinary peptides in CRS. (a) Volcano plot showing the fold change (log2 CRS/Control) plotted against the BH P-value (− log10) of the 559 differentially excreted peptides between CRS and controls. The top five most representative protein precursors including COL1A1, COL3A1, COL1A2, FGA and UMOD are highlighted in different colors. (b) Pie chart of the top 15 most frequently observed protein precursors, associated with at least 400 differentially excreted CRS-associated peptides. The percentage of the differentially excreted peptides per protein precursor is presented. 55.9% of CRS-associated peptides originated from fibril-forming collagens and were fragments of COL1A1, COL1A2, and COL3A1. (c) Heatmap of the log2 transformed fold change of the top 10 most increased and decreased peptides in the CRS cohort. In each case, the peptide codes are provided in Supplementary Table S1.
