Table 2 Univariate and multivariate survival analyses of OS and DFS in HNSCC patients.

From: Comprehensive analysis of immune cell enrichment in the tumor microenvironment of head and neck squamous cell carcinoma

Variables

Disease free survival

Overall survival

Univariate

Multivariate

Univariate

Multivariate

p value

HR (95% CI)

p value

p value

HR (95% CI)

p value

HPV status

Negative

0.027

1

0.037

0.132

  

Positive

0.566 (0.331–0.967)

Primary lesion

Hypopharynx

0.158

  

0.140

  

Larynx

Oral cavity

Oropharynx

T factor

T0-2

0.001

1

0.132

0.0002

1

0.016

T3-4

1.474 (0.889–2.444)

1.839 (1.118–3.026)

N factor

Negative

0.06

  

0.037

1

0.217

Positive

1.267 (0.870–1.846)

M factor

M0

0.26

  

0.001

1

0.0005

M1

6.263 (2.215–17.707)

TNM stage

I–II

0.009

1

0.254

0.009

1

0.483

III–IV

1.457 (0.763–2.782)

0.788 (0.405–1.534)

Immune signature

Cold

0.320

  

0.005

1

 

Lymphocyte

0.362 (0.172–0.763)

0.008

Myeloid/DC

1.077 (0.780–1.486)

0.654

  1. DFS Disease free survival, OS Overall survival, HNSCC Head and neck squamous cell carcinoma, HR Hazard ratio, CI Confidence interval, DC Dendritic cell.
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