Table 1 Mizoroki–Heck reaction between iodobenzene and n-butyl acrylate catalyzed by γ-Fe2O3@MBD/Pd-Co using water.

From: A new nanomagnetic Pd-Co bimetallic alloy as catalyst in the Mizoroki–Heck and Buchwald–Hartwig amination reactions in aqueous media

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Entry[a]

Catalyst (mol%)[b]

Base

Time (min)

Isolated yield (%)

1

0.03

Et3N

60

91

2

0.04

Et3N

60

97

3

0.05

Et3N

25

99

4

–

Et3N

24 h

Trace

5

0.05

K2CO3

75

92

6

0.05

CsCO3

65

85

7

0.05

Na2CO3

120

85

8

0.05

NaHCO3

120

81

9

0.05

KOH

85

78

10

0.05

NaOEt

30

92

11

0.05

–

70

91

12[c]

0.05

Et3N

60

93

13[d]

0.05

Et3N

24 h

65

  1. [a] Reaction conditions: iodobenzene (1 mmol), n-butyl acrylate (1.3 mmol), base (2 mmol), water (1 mL), 60 °C (except for entries 12 and 13), [b] based on the Pd content, [c] 50 °C, [d] room temperature.
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