Figure 1
From: The ABCC4 gene is associated with pyometra in golden retriever dogs
GWAS of pyometra in golden retrievers. (a) QQ-plot (λ = 0.99) and (b) Manhattan plot for GWAS of 98 cases and 96 controls identified a genome-wide significant signal on chromosome 22. Stippled line shows Bonferroni corrected significance threshold. (c) QQ-plot and (d) Manhattan plot of conditional GWAS using the genotype for one of the most associated SNPs (chr22: 45,875,420) on chromosome 22 as covariate, illustrating a slightly stronger association on chromosome 18, and the disappearance of the association on chromosome 28. (e) QQ-plot and (f) Manhattan plot for age of onset analysis showed two suggestive loci on chromosome 15 and 32.
