Table 1 Baseline characteristics of thalassemic women and controls.

From: Pregnancy outcomes in women affected by fetal alpha-thalassemia: a case control study

Characteristics

Control group (n = 437,382)

Women with the α-thalassemia trait*

P1§ (P2)

Normal fetal group (n = 446)

Fetal group with α-thalassemia trait (n = 708)

Fetal group with HbH disease (n = 211)

Maternal age (y)

0.100 (.254)

12–19

12,956 (2.96)

11 (2.47)

18 (2.54)

11 (5.21)

 

20–34

346,994 (79.33)

353 (79.15)

573 (80.93)

155 (73.46)

 

35–58

77,432 (17.70)

82 (18.39)

117 (16.53)

45 (21.33)

 

Maternal anemia (Hb < 10 g/dL)

37,864 (8.66)

68 (15.25)

133 (18.79)

42 (19.91)

0.213 (< .001)

Number of prenatal visits > 10

206,526 (47.22)

245 (54.93)

376 (53.11)

118 (55.92)

0.709 (< .001)

Gestational weeks at first visit

0.051 (.062)

< 13

320,425 (73.26)

317 (71.08)

526 (74.29)

139 (65.88)

 

13–42

116,957 (26.74)

129 (28.92)

182 (25.71)

72 (34.12)

 

Gravidity

0.461 (.069)

1

100,526 (22.98)

105 (23.54)

188 (26.55)

57 (27.01)

 

2–23

336,856 (77.02)

341 (76.46)

520 (73.45)

154 (72.99)

 

Parity

0.080 (< .001)

Nulliparous

165,076 (37.74)

213 (47.76)

331 (46.75)

117 (55.45)

 

Parous

272,306 (62.26)

233 (52.24)

377 (53.25)

94 (44.55)

 

Ethnic group

0.311 (< .001)

Han

228,462 (52.23)

185 (41.48)

323 (45.62)

94 (44.55)

 

Zhuang

193,659 (44.28)

244 (54.71)

371 (52.40)

111 (52.61)

 

Others

15,261 (3.49)

17 (3.81)

14 (1.98)

6 (2.84)

 

Residency in Guangxi province

411,730 (94.14)

442 (99.10)

702 (99.15)

209 (99.05)

0.989 (< .001)

  1. Data are n (%) unless otherwise specified. *Includes two types of heterozygous mutations, –SEA/αα (99.12%) and –THAI/αα (0.88%). Includes two types of heterozygous mutations, –SEA/αα (98.45%) and –THAI/αα (1.55%). There were 184 deletional HbH diseases (–/–α) and 27 non-deletional HbH diseases (–/αTα). Deletional HbH diseases comprised –SEA/–α3.7 (64.67%) and –SEA/–α4.2 (35.33%), while non-deletional HbH diseases comprised –SEACSα (92.59%) and –SEAQSα (7.41%). §Chi-squared test for three subgroups. Chi-squared test for all groups.