Table 3 Only SMARTREAB desaturators and both desaturators compared.

	Group C	Group D	Difference of means or medians*	95% CI	P-value
	N = 27	N = 64	Difference of means or medians*	95% CI	P-value
Age (years; mean ± SD)	62.8 ± 12.0	67.7 ± 8.1	− 4.8 ± 2.2	− 9.1 to − 0.5	0.028**
Pulmonary function
FVC pred (%; mean ± SD)	94.7 ± 19.9	73.7 ± 25.4	21.1 ± 5.0	11.1 to 31.0	< 0.0005**
DLCO pred (%; mean ± SD)	71.0 ± 23.8	49.7 ± 22.2	21.2 ± 5.9	9.2 to 33.2	0.001**
6MWT
6MWD (m; mean ± SD)	375.6 ± 121.6	296.5 ± 103.8	79.1 ± 26.8	25.1 to 133.0	0.005**
Nadir SpO₂ (%; mean ± SD)	92.4 ± 1.8	83.1 ± 5.4	9.3 ± 1.1	7.2 to 11.4	< 0.0005**
Peak HR (%; mean ± SD)	67.2 ± 10.6	72.9 ± 12.4	− 5.7 ± 2.6	− 10.8 to − 0.6	0.030**
Activity intensity (MET; mean ± SD)	2.8 ± 0.6	2.4 ± 0.5	0.4 ± 0.1	0.1 to 0.6	0.005**
Number of pauses (n; median, IQR)	0 (0–0)	0 (0–1)	− 2.5	–	0.016***
Number of periods SpO₂ < 90% (n; median, IQR)	0 (0–0)	1 (1–2)	− 8.1	–	< 0.0005***
SMARTREAB telemonitoring
Nadir SpO₂ (%; mean ± SD)	80.3 ± 5.8	76.5 ± 7.6	3.8 ± 1.5	0.9 to 6.7	0.011**
Peak HR (%; mean ± SD)	80.5 ± 11.3	80.2 ± 11.4	0.3 ± 2.6	− 4.9 to 5.5	0.905**
Activity intensity (MET; mean ± SD)	3.1 ± 0.7	2.8 ± 0.6	0.3 ± 0.2	0.0 to 0.6	0.069**
Daily episodes SpO₂ < 90% (n; median, IQR)	2 (1–5)	9 (5–17)	− 4.3	–	< 0.0005***
Longest period SpO₂ < 90% (min; mean ± SD)	25.4 ± 41.8	32.8 ± 35.4	− 7.4 ± 9.2	− 26.0 to 11.1	0.424**

*Means and medians calculated independently.
**Independent sample t-test.
***Independent sample Mann–Whitney U test.
Group C: only SMARTREAB telemonitoring desaturators; Group D: six-minute walk test and SMARTREAB telemonitoring desaturators; CI: confidence interval; SD: standard deviation; IQR: interquartile range; FVC pred: predicted forced vital capacity; DLCO pred: predicted diffusion capacity of the lungs for carbon monoxide; 6MWT: six-minute walk test; 6MWD: six-minute walk distance; nadir SpO₂: lowest peripheral oxygen saturation detected; HR: heart rate; MET: metabolic equivalent of task.

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