Table 2 Association between DTI and GM atrophy measures and white matter lesion volume in each group of MS patients.

From: Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients

GM MRI metrics

Number of regions

Median β (95% CI)

Median p value

Mean diffusivity

 MS1

4/4

0.485 (0.27, 0.7)

< 0.001

 MS2

14/14

0.374 (0.19, 0.56)

< 0.001

 MS3

27/64

0.308 (0.11, 0.51)

0.014

Increased fractional anisotropy

 MS1

0/2

NS

NS

 MS2

0/4

NS

NS

 MS3

3/21

0.394 (0.21, 0.58)

0.003

Decreased fractional anisotropy

 MS1

0

–

–

 MS2

0

–

–

 MS3

0/3

NS

NS

Volume

 MS1

4/4

− 0.369 (− 0.57, − 0.17)

0.004

 MS2

11/19

− 0.25 (− 0.41, − 0.09)

0.021

 MS3

12/69

− 0.338 (− 0.54, − 0.14)

0.016

  1. Analyses were performed with the GM regions showing abnormal diffusion or volume in each group of patients.
  2. CI, confidence interval; MS, multiple sclerosis; NS, not significant.
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