Table 2 Top variant results from discovery and replication meta-analysis.

From: Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity

Variant rsID

Chr

Position (hg19)

Nearest Gene

Position respect to the Nearest Gene

EA

EAF

Discovery

Replication

Meta-analysis

Beta

SE

p-value

Beta

SE

p-value

Effect direction

Beta

SE

p-value

rs10037643

5

60,565,864

LINC02057

5.1 Kb upstream

A

0.46

0.023

0.005

6.92 × 10–7

0.002

0.009

0.822

 +  + 

0.018

0.004

7.00 × 10–6

rs77619310

7

22,252,636

RAPGEF5

Intronic

A

0.04

0.058

0.012

7.22 × 10–7

0.031

0.025

0.219

 +  + 

0.053

0.011

5.27 × 10–7

rs17296631

10

33,766,736

NRP1

142.9 Kb upstream

T

0.04

0.064

0.013

4.47 × 10–7

0.066

0.024

5.47 × 10–3

 +  + 

0.065

0.011

8.36 × 10–9

rs9551465

13

28,962,757

FLT1

Intronic

T

0.54

0.023

0.005

9.93 × 10–7

0.019

0.008

0.024

 +  + 

0.022

0.004

7.84 × 10–8

rs61755606

17

40,940,579

WNK4

Intronic

A

0.11

0.039

0.007

2.50 × 10–7

0.013

0.016

0.399

 +  + 

0.034

0.007

5.25 × 10–7

  1. Chr chromosome, EA effect allele, EAF effect allele frequency, SE standard error, Effect Direction: direction of the effect allele on PlGF levels in Discovery and Replication.
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