Table 3 Significantly enriched pathways.

From: Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity

Gene ontologies

GO term

q-value

Dispensability

BP

GO:0006491N-glycan processing

0.042

0

BP

GO:0016064 immunoglobulin mediated immune response

7.23 × 10–4

0

BP

GO:0006959 humoral immune response

0.036

0.692

BP

GO:0042129 regulation of T cell proliferation

0.035

0.637

BP

GO:0002377 immunoglobulin production

3.69 × 10–3

0.632

BP

GO:0002889 regulation of immunoglobulin mediated immune response

0.040

0.947

BP

GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response

0.035

0.952

BP

GO:0034112 positive regulation of homotypic cell–cell adhesion

0.036

0.722

BP

GO:0019724 B cell mediated immunity

1.42 × 10–3

0.924

BP

GO:0002712 regulation of B cell mediated immunity

0.040

0.947

BP

GO:0002440 production of molecular mediator of immune response

5.25 × 10–3

0.627

BP

GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

0.043

0.933

BP

GO:0002637 regulation of immunoglobulin production

0.049

0.888

BP

GO:1903039 positive regulation of leukocyte cell–cell adhesion

0.040

0.979

BP

GO:0002455 humoral immune response mediated by circulating immunoglobulin

0.035

0.952

BP

GO:0050870 positive regulation of T cell activation

0.039

0.933

CC

GO:0042613 MHC class II protein complex

1.83 × 10–5

0

CC

GO:0042611 MHC protein complex

3.21 × 10–3

0.501

CC

GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

4.37 × 10–3

0.032

CC

GO:0098576 lumenal side of membrane

0.035

0.513

CC

GO:0098553 lumenal side of endoplasmic reticulum membrane

4.37 × 103

0.606

MF

GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

6.87 × 10–3

0

MF

GO:0030983 mismatched DNA binding

1.42 × 10–3

0

MF

GO:0032395 MHC class II receptor activity

8.59 × 10–5

0

MF

GO:0005542 folic acid binding

0.036

0.066

MF

GO:0017091 AU-rich element binding

0.040

0.149

MF

GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors

0.035

0.299

  1. Gene Ontologies: Molecular Function (MF), Biological Process (BP), Cellular Component (CC). Dispensability represents a measure of the non-redundancy of a GO term with respect to other semantically close terms. Representative, non-redundant GO terms are given in black, the other cluster members are in italics.
Back to article page