Figure 2 | Scientific Reports

Figure 2

From: Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons

Figure 2

Dopaminergic induction of human ESCs reveals transcriptional dynamic profiles composed of both protein-coding genes and lncRNAs. (a) Venn diagram showing the extent of overlap of DEGs found from pairwise comparisons. (b) Number of DE protein-coding genes and lncRNAs found in each pairwise comparison. (c) Hierarchical clustering analysis displaying temporal expression profiles of all 4009 DEGs compiled from time-point pairwise comparisons. Highly enriched gene-sets and ontologies were identified (hypergeometric test with FDR < 0.05). The enrichment of gene-sets is indicated as − log10(FDR), with the number of genes indicated in parenthesis. Heatmap was built using row z-scores of log2 transformed FPKM gene expression values.

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