Figure 3

Correlation between CD activity as well as Ig-coated bacteria and fecal free Ig concentration. (a) The correlation between the ratio of each Ig-coated bacteria and the CDAI score is shown in the graph. The CDAI score was obtained at the time of fecal sample collection (n = 22). (b) Box plot showing the flow cytometry analysis results for the ratio of each Ig-coated bacteria in the CD-A (n = 8) and CD-R (n = 14) samples. CD-A was more correlated with the ratio of each Ig-coated bacteria than CD-R. Disease activity was defined based on the CDAI score. (c) The CDAI score was correlated with the concentration of each fecal free Ig. (d) Box plot showing the concentration of each fecal free Ig in the CD-A (n = 8) and CD-R (n = 11) samples. Unlike CD-R, CD-A was not correlated with the concentration of each fecal free Ig. Spearman’s correlation analysis was performed, and the straight line in graphs (a) and (c) is the regression line. The brackets in graphs (b) and (d) indicate significant differences. Wilcoxon rank-sum test. p-values are shown *< 0.05, **< 0.005. Student’s t-test. p-values are shown ^†< 0.05, ^††< 0.005). CD Crohn’s disease, CDAI Crohn’s Disease Activity Index, CD-A Crohn’s disease in the active phase, CD-R Crohn’s disease in the active phase.