Table 3 The diagnostic value of FIB, d-dimer and FDP for RA.
From: Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis
Parameters | AUC | 95% CI | Optimal cut-off value | Specificity (%) | Sensitivity (%) | PPV (%) | NPV (%) | AC (%) |
|---|---|---|---|---|---|---|---|---|
RA vs. control | ||||||||
FIB (mg/dL) | 0.782 | 0.712–0.842 | > 286 | 75.61 | 78.91 | 76.39 | 78.19 | 77.26 |
d-dimer (μg/L) | 0.777 | 0.706–0.837 | > 470 | 77.50 | 68.75 | 75.34 | 77.50 | 73.13 |
FDP (mg/L) | 0.762 | 0.691–0.825 | > 1.45 | 77.50 | 71.09 | 75.96 | 72.83 | 74.30 |
Active vs. low activity RA | ||||||||
FIB (mg/dL) | 0.755 | 0.666–0.830 | > 390 | 82.35 | 57.81 | 66.12 | 76.61 | 70.08 |
d-dimer (μg/L) | 0.825 | 0.743–0.889 | > 1230 | 88.24 | 65.62 | 71.96 | 84.80 | 76.93 |
FDP (mg/L) | 0.793 | 0.708–0.863 | > 1.81 | 66.67 | 81.25 | 78.05 | 70.91 | 73.96 |
CRP (mg/L) | 0.732 | 0.642–0.810 | > 5.41 | 84.31 | 67.69 | 72.29 | 81.18 | 76.00 |
ESR (mm/h) | 0.588 | 0.428–0.736 | > 10 | 86.75 | 31.25 | 55.79 | 70.22 | 59.00 |
