Figure 3
From: Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma
NO2-OA improves lung function in obese mice with AAD. Lung function was evaluated following NO2-OA treatment in obese mice with HDM-induced allergic airway disease. (A) Pulmonary resistance (Rrs), (B) pulmonary elastance (Ers), (C) airway resistance (Rn), (D) tissue damping (G), and (E) tissue elastance (H) were measured at baseline and following administration of increasing doses of methacholine using a flexiVent system. Graphs show data for control (n = 2–5), vehicle (n = 6–13), and NO2-OA (n = 8–13) and combined from four independent experiments. *p < 0.05, ****p < 0.0001.
