Figure 4

The timepoints at which significant changes occurred. Timepoints at which significant seizure-related changes occur are shown in the box-and-whisker plots. Median timepoints of each group are indicated as numerical values and the center mark on each box. For HFA and ISA, the change in the SOZ contacts occurs significantly before that of the nSOZ contacts. The time of PAC (i.e., ISA-HFA SIm) is earlier than that of SO (0 s). No significant differences exist between the times of SOZ-PAC and nSOZ-PAC. **Corrected p < 0.01, Wilcoxon rank-sum test across contacts, nine multiple comparison corrected by Bonferroni method.