Table 2 Physicochemical characterization of UroGm-Etp-SNs.

From: Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer

Formulation

Zetasizer

Nanosight

Size (nm)

PdI

ZP (mV)

Size (nm)

D10

D50

D90

SPAN

Conc. (particles/mL)

Etp-SNs

141 ± 8

0.2

− 34 ± 3

155 ± 3

110 ± 2

141 ± 3

209 ± 9

0.70

4.3 × 1011 ± 3.3 × 1010

UroGm-Etp-SNs

126 ± 14

0.2

− 45 ± 5

122 ± 2

81 ± 1

108 ± 2

173 ± 3

0.85

5.6 × 1011 ± 1.8 × 1010

  1. nm: nanometer, PdI: polydispersity index, ZP: zeta potential in millivolts (mV), SNs: Sphingomyelin nanosystems, Etp: Etoposide, UroGm: Modified Uroguanylin, (mean ± SD; n ≥ 3).
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