Figure 9 | Scientific Reports

Figure 9

From: Reveals of candidate active ingredients in Justicia and its anti-thrombotic action of mechanism based on network pharmacology approach and experimental validation

Figure 9

Gene chip detection confirmed that justicidin D can cause the differential expression of 21 genes out of 48 common genes. (A) Volcano plot, justicidin D caused high expression of 2392 genes and low expression of 3268 genes. (B) Among the 48 common genes in the network analysis, we have determined that 21 genes have significant differential expression. Red is high expression and green is low expression. (C) GO enrichment entries for 21 differentially expressed genes. (D) KEGG enrichment analysis showed the first five signaling pathways. (E) The most important biological process enriched is the positive regulation of cell migration, which displays the differentially expressed gene network, the core part of which is composed of APP, PTGS2, IL1B, IL6, and TNF.

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