Table 4 Clusters of the disease target PPI network.

From: Reveals of candidate active ingredients in Justicia and its anti-thrombotic action of mechanism based on network pharmacology approach and experimental validation

Cluster

Score

Nodes

Edges

Gene IDs

1

56.32

64

1774

CRP, FOXP3, TLR4, TLR2, CXCL12, SRC, JUN, FASLG, CD40, CCL2, PTGS2, SELL, MPO, CD40LG, IFNG, TGFB1, IL17A, MMP2, CASP3, CD34, CSF3, FCGR2B, TLR9, ANXA5, GZMB, ALB, STAT1, NOTCH1, FAS, TP53, TNFRSF1A, SELE, STAT3, JAK2, ICAM1, SELP, IL2, NLRP3, CD86, CXCL8, MMP9, CXCR4, HMGB1, ITGAM, TLR5, PRF1, CXCL10, CTLA4, IL10, CSF2, FN1, IL3, IL4, IL18, VEGFA, AKT1, TNF, CD274, CD44, TLR7, IL6, IL1B, IL7, MAPK8

2

10.00

38

185

PROS1, PDGFRA, PLAU, F5, FYN, CTNNB1, MET, GAS6, SERPINF2, ANGPT1, FGA, CD47, FGB, CYCS, ACE, TFRC, PF4, IL23R, THBD, SIRT1, F13A1, THPO, CDC42, F8, THBS1, CDH5, ENTPD1, SPARC, APP, EGR1, STAT4, SMAD4, ANGPT2, ACTN1, VWF, PDCD1, IL11, MMRN1

3

8.97

34

148

HAVCR2, IFNA1, PLG, FCGR2A, TNFSF13B, EPO, PTEN, IL17F, ELANE, GPT, ITGB1, SYK, IL1A, SERPINE1, HIF1A, F3, FCGR1A, LYN, WDTC1, ENG, IL1RN, PECAM1, CD209, KITLG, CCR1, IL9, ERBB2, TBX21, IFNB1, KDR, ITGAL, NOS3, EDN1, APOE

4

8.16

26

104

CPB2, F11, F12, CFH, MPL, SAA1, FGG, P4HB, OXGR1, IL12A, CASR, P2RY12, SERPINC1, PPBP, PTGER3, F7, GATA2, C3AR1, PROC, GATA1, F9, LGALS1, SERPIND1, C4A, HABP2, ITGA2B

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