Figure 6
HES gene expression in metazoan organogenesis. Lophotrochozoa: Mollusca: Expression is in ectodermal cells of pre-larval stages and subsequently during mesoderm formation as well as in neurogenesis and development of the digestive tract. Annelida: Expression is during formation of the digestive tract, neurogenesis, segmentation, and chaetogenesis. Brachiopoda: Expression is in the ectoderm of pre-larval stages, during early mesoderm formation, and in chaetogenesis. Ecdysozoa: Hexapoda: Expression is during segment formation. Nematoda: Expression is during neurogenesis. Deuterostomia: Echinodermata: Expression is in the larval ectoderm. In the late pluteus larva, HES expression is in the region of the apical organ. Chordata: Expression is during neurogenesis, somitogenesis, and in the digestive tract. Xenacoelomorpha: Expression is during neurogenesis. Cnidaria: Expression is in the ectoderm and endoderm of early developmental stages and during budding in hydrozoans. Data from previous investigations19,21,35,36,37,38,81,82,83,84,85 and present study. Expression pattern schemes were designed with Inkscape (version 0.92.4; https://inkscape.org) and Gimp 2 (Version 2.8.22; https://www.gimp.org).
