Table 4 Salivary cytokines in stroke patients and healthy controls.
From: Salivary cytokine profile in patients with ischemic stroke
Salivary biomarker | NWS | SWS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Control n = 25 | Stroke n = 25 | p value | Control n = 25 | Stroke n = 25 | p value | |||||
Mean ± SD | 95% CI | Mean ± SD | 95% CI | Mean ± SD | 95% CI | Mean ± SD | 95% CI | |||
TNF-α | ||||||||||
Concentration (pg/mL) | 11.72 ± 3.503 | 10.27–13.16 | 27.93 ± 6.021 | 25.44–30.41 | < 0.0001 | 4.02 ± 0.6272 | 3.761–4.279 | 6.776 ± 0.8391 | 6.43–7.122 | < 0.0001 |
Output (pg/min) | 3.731 ± 1.181 | 3.244–4.218 | 11.07 ± 7.472 | 7.989–14.16 | < 0.0001 | 3.649 ± 1.189 | 3.158–4.14 | 3.947 ± 1.768 | 3.217–4.677 | 0.4884 |
Specific amount (ng/mg protein) | 9.846 ± 3.591 | 8.364–11.33 | 26.63 ± 11.21 | 22–31.25 | < 0.0001 | 3.106 ± 0.5689 | 2.871–3.341 | 7.702 ± 2.53 | 6.658–8.746 | < 0.0001 |
IL-6 | ||||||||||
Concentration (pg/mL) | 15.81 ± 3.715 | 14.28–17.34 | 29.27 ± 9.684 | 25.28–33.27 | < 0.0001 | 6.996 ± 0.8605 | 6.64–7.351 | 11.3 ± 1.065 | 10.86–11.74 | < 0.0001 |
Output (pg/min) | 5.213 ± 1.863 | 4.443–5.982 | 11.68 ± 8.251 | 8.27–15.08 | 0.0004 | 6.37 ± 2.004 | 5.543–7.197 | 6.487 ± 2.655 | 5.391–7.583 | 0.8614 |
Specific amount (ng/mg protein) | 13.27 ± 3.674 | 11.75–14.79 | 26.89 ± 9.536 | 22.95–30.82 | < 0.0001 | 5.449 ± 1.094 | 4.997–5.9 | 12.8 ± 3.838 | 11.21–14.38 | < 0.0001 |
IL-10 | ||||||||||
Concentration (pg/mL) | 3.934 ± 0.7284 | 3.634–4.235 | 2.078 ± 0.8456 | 1.728–2.427 | < 0.000 | 0.5012 ± 0.07068 | 0.4721–0.5304 | 0.1753 ± 0.085 | 0.1402–0.2104 | < 0.0001 |
Output (pg/min) | 0.4502 ± 0.1308 | 0.3962–0.5042 | 0.09977 ± 0.05173 | 0.07842–0.1211 | 0.0031 | 1.287 ± 0.3666 | 1.136–1.438 | 0.8238 ± 0.6476 | 0.5564–1.091 | < 0.0001 |
Specific amount (ng/mg protein) | 3.303 ± 0.8475 | 2.953–3.653 | 1.927 ± 0.9295 | 1.543–2.31 | < 0.0001 | 0.3881 ± 0.07196 | 0.3584–0.4178 | 0.2015 ± 0.1105 | 0.1559–0.2471 | < 0.0001 |
TNF-α/IL-10 | ||||||||||
Ratio | 3.119 ± 1.285 | 2.588–3.649 | 18.96 ± 17.54 | 11.71–26.2 | < 0.0001 | 8.186 ± 1.776 | 7.452–8.919 | 58.24 ± 56.44 | 34.94–81.54 | < 0.0001 |
IL-6/IL-10 | ||||||||||
Ratio | 4.156 ± 1.28 | 3.627–4.684 | 19.88 ± 22.59 | 10.56–29.21 | 0.0011 | 14.33 ± 3.247 | 12.99–15.67 | 95.8 ± 86.71 | 60.01–131.6 | < 0.0001 |
