Table 7 Receiver operating characteristics of salivary cytokines in stimulated saliva of stroke patients and healthy controls.
From: Salivary cytokine profile in patients with ischemic stroke
Salivary biomarker | SWS | |||||||
|---|---|---|---|---|---|---|---|---|
AUC | 95% CI | p-value | Cut off | Sensitivity% | 95% CI | Specificity% | 95% CI | |
TNF-α | ||||||||
Concentration (pg/mL) | 0.9984 | 0.9931–1.000 | < 0.0001 | > 4.941 | 100 | 86.68–100.0 | 96 | 80.46–99.79 |
Output (pg/min) | 0.5616 | 0.3950–0.7282 | 0.4551 | > 4.211 | 52 | 33.50–69.97 | 76 | 56.57–88.50 |
Specific amount (ng/mg protein) | 1 | 1.000–1.000 | < 0.0001 | > 4.249 | 100 | 86.68–100.0 | 100 | 86.68 -100.0 |
IL-6 | ||||||||
Concentration (pg/mL) | 1 | 1.000–1.000 | < 0.0001 | > 8.986 | 100 | 86.68–100.0 | 100 | 86.68–100.0 |
Output (pg/min) | 0.536 | 0.3704–0.7016 | 0.6624 | > 6.640 | 60 | 40.74–76.60 | 60 | 40.74–76.60 |
Specific amount (ng/mg protein) | 0.9968 | 0.9882–1.000 | < 0.0001 | > 8.366 | 96 | 80.46–99.79 | 100 | 86.68–100.0 |
IL-10 | ||||||||
Concentration (pg/mL) | 0.9984 | 0.9931–1.000 | < 0.0001 | < 0.3165 | 96 | 80.46–99.79 | 100 | 86.68–100.0 |
Output (pg/min) | 1 | 1.000–1.000 | < 0.0001 | < 0.2250 | 100 | 86.68–100.0 | 100 | 86.68–100.0 |
Specific amount (ng/mg protein) | 0.9136 | 0.8353–0.9919 | < 0.0001 | < 0.2665 | 76 | 56.57–88.50 | 96 | 80.46–99.79 |
TNF-α/IL-10 | 1 | 1.000–1.000 | < 0.0001 | > 17.01 | 100 | 86.68–100.0 | 100 | 86.68–100.0 |
IL-6/IL-10 | 1 | 1.000–1.000 | < 0.0001 | > 24.60 | 100 | 86.68–100.0 | 100 | 86.68–100.0 |
