Table 1 Constantly differentially expressed miRNAs throughout all 3 clinical time points using all 3 RNA-seq analysis tools in dogs with X-linked hereditary nephropathy versus controls (T1 = onset of proteinuria, T2 = onset of azotemia, T3 = advanced CKD).
Analysis tools | miRNAs | T1 | T2 | T3 | |||
|---|---|---|---|---|---|---|---|
Log2 fold change | Adjusted P-value | Log2 fold change | Adjusted P-value | Log2 fold change | Adjusted P-value | ||
miRDeep2 | miR-21 | 2.33 | 1.23E−05 | 1.89 | 5.31E−04 | 1.74 | 1.84E−03 |
miR-142 | 1.65 | 1.72E−03 | 2.21 | 4.42E−04 | 1.10 | 4.37E−02 | |
miR-146b | 2.36 | 8.18E−04 | 3.31 | 1.77E−05 | 2.03 | 5.06E−04 | |
miR-802 | 3.42 | 1.70E−05 | 4.37 | 6.42E−07 | 2.80 | 1.54E−04 | |
CPSS 2.0 | miR-21 | 2.30 | 4.66E−05 | 1.91 | 1.25E−03 | 1.72 | 3.48E−03 |
miR-142 | 1.67 | 2.35E−03 | 2.22 | 8.25E−04 | 1.13 | 4.07E−02 | |
miR-146b | 2.33 | 1.84E−03 | 1.85 | 1.02E−02 | 2.01 | 5.47E−04 | |
miR-147 | 2.16 | 2.47E−02 | 3.27 | 8.25E−04 | 2.16 | 2.47E−02 | |
miR-802 | 3.37 | 6.07E−05 | 4.20 | 4.09E−06 | 2.80 | 8.03E−05 | |
OmicSoft Studio | miR-21 | 2.30 | 5.41E−05 | 1.95 | 9.22E−04 | 1.76 | 2.93E−03 |
miR-146b | 2.32 | 2.32E−03 | 3.27 | 8.46E−05 | 2.06 | 3.29E−04 | |
miR-147 | 2.02 | 4.69E−02 | 2.02 | 4.69E−02 | 1.94 | 2.91E−02 | |
miR-802 | 3.31 | 7.33E−05 | 4.28 | 2.90E−06 | 2.86 | 8.37E−05 | |
