Figure 1
From: Predicting hosts based on early SARS-CoV-2 samples and analyzing the 2020 pandemic
DeepHoF outperforms BLAST. (a) Average ROC curves and AUC values of DeepHoF and BLAST. DeepHoF performs better than BLAST on average AUC of five host types. (b) Comparison of human host likelihood scores predicted by DeepHoF between human-infecting and non-human-infecting coronaviruses on human. The former performed higher probabilities than the latter (two-sided unpaired Welch Two Sample t test, t(43.843) = 8.265 and t(38.016) = 4.674, p values = 1.732 × 10–10 and 3.657 × 10–5. ***: p value \(<\) 0.0001, t values and degrees of freedom were presented as t(df)). (c,d) Phylogenetic analyses of whole genomes and S genes of coronaviruses respectively. Maximum-likelihood phylogenic trees were built by RAxML39 with 1000 bootstrap replicates and visualized with iTOL41. There were clear non-human-infecting gaps between closely related human-infecting coronaviruses in the phylogenetic trees for either whole genomes or S genes. For some human-infective viruses, their closest neighbors in phylogeny were non-human-infective ones (red: human-infective coronaviruses; blue: non-human-infective coronaviruses).
