Table 4 Per-protocol secondary analysis. Diagnostic test values using the composite reference standard (Tuberculosis treatment and microbiological results) n = 166.
Composite reference standard (TB treatment initiation n = 166) | ||||
|---|---|---|---|---|
Sensitivity (95%CI*) | Specificity % (95%CI) | PPV§ (95%CI) | NPV# (95%CI) | |
Overall | ||||
Smear microscopy | 0.33 (0.20;0.48) | 1.00 (0.97; 1.00) | 1.00 (0.78; 1.00) | 0.79 (0.72; 0.86) |
Xpert MTB/RIF | 0.52 (0.37;0.67) | 1.00 (0.97; 1.00) | 1.00 (0.86; 1.00) | 0.85 (0.77; 0.90) |
RT-MTB | 0.65 (0.50; 0.79) | 0.82 (0.74; 0.88) | 0.58 (0.43; 0.71) | 0.86 (0.78; 0.92) |
p value = 0.1 | p value < 0.001 | |||
Smear negative (n = 151) | ||||
Xpert MTB/RIF | 0.29 (0.14;0.48) | 1.00 (0.97; 1.00) | 1.00 (0.66;1.00) | 0.85 (0.77;0.90) |
RT-MTB | 0.48 (0.30;0.67) | 0.82 (0.74; 0.88) | 0.41 (0.25;0.58) | 0.86 (0.78;0.92) |
p value = 0.05 | p value < 0.001 | |||
Smear positive (n = 15) | ||||
Xpert MTB/RIF | 1.00 (0.78; 1.00) | – | 1.00 (0.78; 1.00) | – |
RT-MTB | 1.00 (0.77;1.00) | – | 0.93 (0.68;1.00) | – |
