Table 5 Top disease and biological function predicted by IPA to be associated with NDV infection.

From: Indicators of the molecular pathogenesis of virulent Newcastle disease virus in chickens revealed by transcriptomic profiling of spleen

Disease and functions

Contributed DEGs for prediction

z-Score

No.

Proliferation of cells of the lymphoid system

PLP1, SOX2, GAD2, UNC119, APOH, GAD1, MBP, ADCYAP1, FOXJ1, TYR

− 3.571

168

Quantity of B lymphocytes

SLCO1A2, F3, ST6GALNAC2, FZD9, HGF, PLCD1, ESR1, BST1, ABL1, STAT1

− 2.769

93

Quantity of lymphocytes tissue

GAD2, NPY, SLC4A4, FADS2, FOXC2, PCSK1, YES1, ESR1

ABL1, MXI1

− 2.402

89

Quantity of mononuclear leukocytes

AGT, PLP1, GAD2, MBP, ADCYAP1, SLCO1A2, F3

SNCA, NPY, SLC4A4

− 2.785

172

Microtubule dynamics

AGT, GPM6A, PACSIN1, CAMK2A, SOX2, PHGDH, RFX4, SLC39A12, GRIN1, SNCB

4.311

245

  1. Bold italic and italic text indicates upregulated and downregulated DEGs respectively. Genes are sorted ascendingly from left to right based on their fold change. No. means the number of DEGs in our data contributed to disease production.
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