Figure 4
From: Parasites and diet as main drivers of the Malagasy gut microbiome richness and function
Metabolomic specificities of the microbiome in Malagasy volunteers. Eighteen volunteers were selected according to their enterotypes affiliation (nEnt1 = 5, nEnt2 = 7, nEnt3 = 6) and analysed through metabolomic approach. (A) The inter-class analysis computed upon PCA data emphasizes the stratification of these metabolomes in three clusters, similarly to microbiome enterotypes distribution. (B) Metabolic peaks (n = 51) discriminating the Malagasy metabolomes according to enterotypes stratification. (C) Metabolic functions inferred from PICRUSt that pointed out the functional specificities associated with each enterotypes. Functions listed in the heatmap had a significantly different distribution between enterotypes (p ≤ 0.01) and were selected according to Kruskal Walis’s test followed by a post-hoc Dunn’s test assessing the intergroup (enterotypes) comparison. All tests were corrected for false discovery rate. (D) Functions differentially distributed among protozoan carrier types (0 to > 4).
