Table 2 Top 20 differentially regulated genes identified by RNA sequencing analysis of human obese VAT comparing DM with NDM patients. Significance represented as negative log (base 10) of p-value.

From: The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

Upregulated in DM

Downregulated in DM

Gene name

Gene symbol

LogFC

p-value

Gene name

Gene symbol

LogFC

p-value

Small nucleolar RNA, C/D box 116-18

SNORD116-18

10.00

0.001

Follicular dendritic cell secreted protein

FDCSP

− 10.00

0.001

Matrix metallopeptidase 8

MMP8

4.723

0.001

Microrna 34a

MIR34A

− 10.00

0.050

Matrix metallopeptidase 7

MMP7

3.194

0.027

Complement C3d receptor 2

CR2

− 6.286

0.007

C–C motif chemokine ligand 18

CCL18

3.102

0.001

TNF receptor superfamily member 13C

TNFRSF13C

− 4.536

0.049

Secreted phosphoprotein 1

SPP1

2.939

0.001

Membrane spanning 4-domains A1

MS4A1

− 4.235

0.001

Ring finger protein 128

RNF128

2.706

0.012

Paired box 5

PAX5

− 3.744

0.001

C-X-C motif chemokine ligand 10

CXCL10

2.436

0.001

BLK proto-oncogene, Src fam tyrosine kinase

BLK

− 3.737

0.001

Ribosomal protein S4 Y-linked 1

RPS4Y1

2.208

0.006

Fc receptor like A

FCRLA

− 3.626

0.001

Lipopolysaccharide binding protein

LBP

2.000

0.001

CD19 molecule

CD19

− 3.466

0.001

Ethanolamine-phosphate phospho-lyase

AGXT2L1

1.998

0.014

Fc receptor like 1

FCRL1

− 3.353

0.001

Cholesterol 25-hydroxylase

CH25H

1.858

0.001

Carbonic anhydrase 3

CA3

− 3.241

0.001

Interleukin 1 receptor antagonist

IL1RN

1.857

0.001

C-X-C motif chemokine ligand 13

CXCL13

− 3.136

0.030

Endothelial cell specific molecule 1

ESM1

1.850

0.009

CD79a molecule

CD79A

− 3.110

0.001

Phosphatase and actin regulator 3

PHACTR3

1.790

0.020

WNT inhibitory factor 1

WIF1

− 2.888

0.001

Lipase family member N

LIPN

1.783

0.022

Niban apoptosis regulator 3

FAM129C

− 2.867

0.001

TUB like protein 2

TULP2

1.703

0.031

Fc receptor like 3

FCRL3

− 2.776

0.001

Tudor domain containing 9

TDRD9

1.690

0.005

Cannabinoid receptor 2

CNR2

− 2.627

0.001

Activating transcription factor 3

ATF3

1.670

0.001

ADAM like decysin 1

ADAMDEC1

− 2.574

0.007

Chitinase 1

CHIT1

1.603

0.001

Fc receptor like 2

FCRL2

− 2.343

0.001

Solute carrier family 2 member 5

SLC2A5

1.580

0.001

Makorin ring finger protein 7, pseudogene

MKRN7P

− 2.318

0.037

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