Table 1 Compounds Identified in e-cig smoke solution.

From: Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells

Compound

Concentration (ppm)

Use

Ethylvanillin

12,661.590

Flavoring

Vanillin

1384.183

Flavoring

Acetoin

198.9

Flavoring

Ethylmaltol

70.903

Flavoring

4-Methoxybenzaldehyde (4-Anisaldehyde)

50.552

Flavoring

Methylglyoxal

11.3

Non-flavoring, propylene glycol related compound

Acetaldehyde

10.7

Non-Flavoring, propylene glycol related compound

Syringol (2,6-dimethoxyphenol)

7.753

Flavoring

3-Hydroxy-2-butanone

4.804

Flavoring

Ethyl propionate

4.780

Flavoring

1-Butanol

2.227

Flavoring

2,3-Butanedione (diacetyl)*

2.1

Flavoring

Ethyl acetate

1.325

Flavoring

Piperonal

1.173

Flavoring

Benzaldehyde

0.755

Flavoring

Butyl butyryllactate

0.526

Flavoring

2,3-Dimethylpyrazine

0.524

Flavoring

Ethyl butyrate

0.521

Flavoring

2,4-Dimethylbenzaldehyde

0.471

Flavoring

Pyridine

0.295

Flavoring

Trimethylpyrazine

0.280

Flavoring

Propionaldehyde

0.126

Preservative

  1. *The concentration of diacetyl in our in vitro study was based on the initial Mass-Spec analysis of e-cig smoke solution (89 ppm) in 2016. Due to high volatility, diacetyl in solution quickly decreased since the e-cig solution was first generated.
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