Table 1 Phenotypic characteristics of individuals used for the analyses.

From: HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders

 

GWAS1

GWAS2

All_individuals

847

1292

Age at interview

48.15 (13.78)

46.90 (14.01)

Sex

Men

360 (43%)

565 (44%)

Women

487 (57%)

727 (56%)

Alda scale A score

6.14 (3.05)

6.48 (2.77)

Alda scale total B score

2.16 (1.63)

2.86 (1.69)

Alda scale total score

4.32 (3.36)

3.97 (2.99)

Non responders

186

201

Age at interview

45.56 (11.82)

44.88 (12.66)

Sex

Men

82 (44%)

84 (42%)

Women

105 (56%)

117 (58%)

Alda scale A score

1.63 (1.19)

1.73 (1.22)

Alda scale total B score

2.66 (1.64)

3.56 (1.80)

Alda scale total score

0.38 (0.76)

0.18 (0.49)

Responders

418

685

Age at interview

50.91(14.29)

47.50 (14.70)

Sex

Men

170 (41%)

317 (46%)

Women

248 (59%)

368 (54%)

Alda scale A score

8.78 (1.05)

8.61 (1.08)

Alda scale total B score

1.66 (1.51)

2.50 (1.60)

Alda scale total score

7.12 (2.07)

6.11 (2.12)

Continous (B < 4 exluded)

772

1080

Age at interview

48.49 (13.73)

47.08 (14.05)

Sex

Men

324 (42%)

471 (44%)

Women

448 (58%)

609 (56%)

Alda scale A score

6.25 (3.04)

6.66 (2.74)

Alda scale total B score

1.83 (1.29)

2.36 (1.16)

Alda scale total score

4.65 (3.31)

4.48 (2.89)

  1. Data are n, n (%), or mean (SD). Alda scale refers to the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder; Non-resp = Li non responders (ALDA subscale A less than or equal to 3); Resp = Li responders (ALDA subscale A greater than or equal to 7).