Figure 3
β-catenin knockout attenuates pump dysfunction and chamber dilation after myocardial infarction. (A) Representative short axis, M-mode echocardiographic recordings at the left ventricular mid-papillary level showing attenuation of cardiac function and dilation in β-catenin KO mice post-MI. Echocardiogram was recorded when heart rates were in the 400–500 bpm range. (B) to (D) Summary of echocardiographic parameters of mice up to 8 weeks after MI showing reduced left ventricular dilation in KO mice as measured by end diastolic volume (EDV, panel B, left) and end systolic volume (ESV, panel B, right), attenuation of cardiac systolic dysfunction in KO mice as measured by ejection fraction (panel C, left) and fractional shortening (panel C, right), and unchanged left ventricular posterior wall thickness at diastole (LVPWd, panel D, left) and at systole (LVPDs, panel D, right). n = 10–13 per group. *p < 0.05, **p < 0.01, vs. corresponding sham groups; #p < 0.05, ##p < 0.01, vs. WT MI group at the indicated timepoints. Data were analyzed by two-way ANOVA and Bonferroni post-hoc comparison.
