Figure 4
β-catenin knockout reduces scar sizes after myocardial infarction. (A) Representative images of Masson’s trichrome staining of mouse heart tissue sections at 5 different levels from LAD ligation site (top) to the apex (bottom) at 8 weeks after MI (right), as well as in sham-operated hearts (left). The scar size for each the 5 different levels was calculated as the percentage of fibrotic area (as indicated by the arrows) to the total area of the left ventricle section. The heart’s total scar size was then calculated as the mean of the scar sizes at the 5 levels and reported in panel B. (B) Summary of scar size showing reduced scar size in KO hearts (n = 5) compared to WT hearts (n = 6). Statistical analysis was performed with a two-tailed unpaired t-test.
