Figure 2

Correlation coefficients between the ARX-negative ratio of glucagon-positive cells and various parameters. ARX-negative ratio of glucagon-positive cells (ARX⁻/GCG⁺ ratio) and age (A), BMI (B), HbA1c (C), FPG (D), F-CPR (E), ΔC-peptide (F), relative alpha-cell area (G), relative beta-cell area (H), α/β (I), INS⁺/GCG⁺ ratio (J), and NKX6.1⁺/GCG⁺ ratio (K). Closed circles (●), normal glucose tolerance; open circles (○), impaired glucose tolerance; closed triangles (▲), diabetes; ARX aristaless-related homeobox, FPG fasting plasma glucose, F-CPR fasting C-peptide immunoreactivity, ΔC-peptide increment of C-peptide by glucagon test, α/β alpha- to beta-cell area ratio, NKX6.1 NK homeobox 6.1. Pearson's correlation coefficient was used. r, correlation coefficient; p, p value.