Figure 8

Flowchart showing the regulation of TRPM7 activity by the cell mechanosensitive apparatus components. Lipid raft disruption leads to Src inactivity³⁹. Inactive Src does not phosphorylate FAK¹⁷ and allows RhoA to be excessively active, which leads to excess SF formation and contraction, which causes FA robustness and hampers turnover⁷. The destruction of microtubules has the same effect on FA turnover¹⁶. FAK influences both Rho and MLCK⁴⁰. Inactive MLCK drastically lowers SF tension on the periphery³⁶, which may interfere with FA turnover. All interventions in this system lowered TRPM7 activity. Restricted Ca²⁺ influx affected Ca²⁺-calmodulin-dependent MLCK¹¹ and FA turnover³⁸.