Figure 8
HR ARG studies investigating co-registration of radioligand binding with beta amyloid plaques and phospho-Tau tangles. HR ARG study investigating co-registration of 10 nM [3H]CHDI-180, 10 nM [3H]CHDI-626, 0.1 nM [3H]PiB and 1 nM [3H]T808 with non-HTT fibrillary deposits such as beta amyloid (6E10 antibody) or tau tangles (AT8 antibody). Bound radioligand appears as cluster of silver grains (black dots, orange arrow heads indicate individual silver grains in tissue with low levels of bound radioligand); 6E10- and AT8-positive staining is indicated as blue signal, background was stained with Nuclear Fast red and shows a pink color. Scale represents 20 µm.
