Figure 7 | Scientific Reports

Figure 7

From: Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells

Figure 7

ML141 improved the extension of MK protrusions, but not PLP size, in Y64C-expressing MEG-01 cells. (a) Representative FACS histogram plot of PLP size using FSC as the size parameter. YFP-tagged WT- or Y64C-expressing MEG-01 were treated with VPA for 12 days in the absence or presence of ML141, R-ketorolac or GGT-I298. (b) Geomeans of FSC are the mean ± SEM (n = 4). The results are representative of three independent experiments. Significance was determined by the Bonferroni/Dunn multiple comparison test (c) Cells were cultured for 7 days in the presence of VPA. ML141 was added on day 6 for 24 h. RI values are the mean ± SD (WT, n = 57, M, n = 69, ML141 treated M, n = 53). The results are representative of three independent experiments. Significance was assessed by the Tukey–Kramer multiple comparison test, **P < 0.01, N.S.: not significant P  > 0.05.

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