Figure 2 | Scientific Reports

Figure 2

From: The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

Figure 2

Phylogenetic analysis supports the division of cruzipain sequences into two families. The MEGA-X program was used to construct Maximum Likelihood and Neighbor Joining trees based on aligned amino acid sequences of the central domains of 67 genes encoding cruzipains in Dm28c, CL Brener, and YC6 T. cruzi strains. The numbers at the nodes are the bootstrap values, which were calculated based on 1000 replicates. Cruzipain sequences from Family II are highlighted in gray, and the arrows indicate the cruzipain sequences from Cluster III of the YC6 strain. The sequence of TbrCatL (a.k.a. rhodesain, GenBank: CAC67416.1), the papain-like cysteine protease from Trypanosoma brucei, was used as root.

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