Figure 3 | Scientific Reports

Figure 3

From: The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

Figure 3

Cruzipain proteins can be divided into four sub-types based on structural motifs. (A) Schematic representation of the different domains within cruzipain. (B) Cruzipain 1/cruzain catalytic domain sequence with secondary structure assignment (PDB ID: 3KKU). Blue arrows indicate sheets and red cylinders indicate helices. Highlighted in blue boxes are the motifs used to define the different cruzipain sub-types. (C) Motifs employed to classify cruzipain sequences into sub-types and residues found in each motif for cruzipains, TbrCatL (GenBank: CAC67416.1), and non-parasitic papain-like cysteine proteases – papain (UniProtKB: P00784), from Carica papaya, and human cathepsins retrieved from GenBank under the accession numbers: hCatL NP_001244901.1, hCatS AAC37592.1, hCatK NP_000387.1, hCatF AAF13146.1, hCatB NP_680093.1, hCatH AAL23961.1). Figure generated with Maestro 11.4, Schrödinger, LLC, New York, NY.

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