Table 2 Erythrogram and platelet count of mice treated with ethanolic extract or alkaloid fraction from Aspidosperma nitidum.

From: Evaluation of acute and subacute toxicity of ethanolic extract and fraction of alkaloids from bark of Aspidosperma nitidum in mice

Parameters

Groups

p*

RV25

EE

WCG

LABC

CPqRR

Red blood cells (106/mm3)

6.60 ± 0.44

6.14 ± 1.13

0.251

7.4–11.1

5.8–10.5

Hematocrit (%)

35.36 ± 2.54

37.9 ± 0.56

0.647

34.3–51.3

28.3–68.3

Hemoglobin (g/dL)

13.1 ± 0.36

11.46 ± 2.72

0.346

11.5–15.9

10.1–18.4

MCV

53.5 ± 1.74

52.7 ± 0.49

0.851

46.8–48.0

47.0–51.0

MCH

19.86 ± 0.76

18.5 ± 1.58

0.275

14.1–16.9

14.6–18.5

MCHC

37.1 ± 1.57

35.3 ± 2.66

0.398

30.5–35.4

32.4–37.2

Platelet (103/mm3)

1329.3 ± 29.02

1342.5 ± 72.8

0.439

635–1118

179–1025

 

FA

DCG

P*

LABC

CPqRR

Red blood cells (106/mm3)

6.71 ± 1.38

6.77 ± 0.06

1.000

7.4–11.1

5.8–10.5

Hematocrit (%)

35.33 ± 9.84

37.93 ± 0.75

0.716

34.3–51.3

28.3–68.3

Hemoglobin (g/dL)

12.66 ± 2.40

12.8 ± 0.3

1.000

11.5–15.9

10.1–18.4

MCV

52.1 ± 4.01

55.7 ± 0.79

0.232

46.8–48.0

47.0–51.0

MCH

18.93 ± 2.07

18.5 ± 1.58

0.692

14.1–16.9

14.6–18.5

MCHC

36.4 ± 4.10

35.3 ± 2.66

0.763

30.5–35.4

32.4–37.2

Platelet (103/mm3)

1561 ± 42.4

1336.6 ± 52.4

0.704

635–1118

179–1025

  1. EE ethanolic extract, FA fraction of alkaloids, WCG water control group, DCG DMSO control group (99% water + 1% DMSO), RV reference value, LABC Laboratory Animal Breeding Center, CPqRR René Rachou Research Center.
  2. *p value was obtained by Student's T-test, comparing EE versus WCG, or FA versus DCG.
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