Table 4 Biochemical parameters of mice treated orally with a single dose of ethanolic extract or alkaloid fraction from Aspidosperma nitidum.

From: Evaluation of acute and subacute toxicity of ethanolic extract and fraction of alkaloids from bark of Aspidosperma nitidum in mice

Parameters

Groups

P*

RV25

EE

WCG

LABC

CPqRR

AST (U/L)

88 ± 4.35

77.33 ± 3.05

0.203

64–258

175–193

ALT (U/L)

44.66 ± 3.21

40 ± 3.46

0.034

75–193

32–178

UREA (mg/dl)

45.53 ± 4.29

49.26 ± 4.14

0.345

22–51

27–70

CREATININE mg/dl)

0.24 ± 0.06

0.31 ± 0.03

0.207

0.2–0.6

0.2–0.9

 

FA

DCG

p*

LABC

CPqRR

AST (U/L)

90 ± 7.93

83 ± 8.54

0.357

64–258

175–193

ALT (U/L)

86.66 ± 7.23

39.33 ± 4.72

0.000

75–193

32–178

UREA (mg/dl)

43.86 ± 1.92

49.4 ± 2.66

0.043

22–51

27–70

CREATININE (mg/dl)

0.27 ± 0.06

0.32 ± 0.04

0.378

0.2–0.6

0.2–0.9

  1. EE ethanolic extract, FA fraction of alkaloids, WCG water control group, DCG DMSO control group (99% water + 1% DMSO), AST aspartate aminotransferase, ALT alanine aminotransferase, RV reference value, LABC Laboratory Animal Breeding Center, CPqRR René Rachou Research Center.
  2. *p value was obtained by Student's T-test, comparing EE versus WCG, or FA versus DCG.
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