Table 6 Erythrogram and platelet count of mice treated with repeated doses of ethanolic extract or alkaloid fraction from Aspidosperma nitidum.

From: Evaluation of acute and subacute toxicity of ethanolic extract and fraction of alkaloids from bark of Aspidosperma nitidum in mice

Parameters

Groups

p*

VR25

EE

WCG

LABC

CPqRR

Red blood cells (106/mm3)

8.56 ± 0.30

8.25 ± 0.20

0.391

7.4–11.1

5.8–10.5

Hematocrit (%)

39.27 ± 1.08

38.07 ± 0.61

0.462

34.3–51.3

28.3–68.3

Hemoglobin (g/dL)

14.12 ± 0.35

13.75 ± 0.33

0.624

11.5–15.9

10.1–18.4

MCV

46.15 ± 0.49

46.1 ± 0.54

0.462

46.8–48.0

47.0–51.0

MCH

16.5 ± 0.22

16.67 ± 0.22

0.270

14.1–16.9

14.6–18.5

MCHC

35.92 ± 0.35

36.15 ± 0.23

0.111

30.5–35.4

32.4–37.2

Platelet (103/mm3)

883.66 ± 24.13

765 ± 39.59

1.000

635–1118

179–1025

 

FA

DCG

p*

LABC

CPqRR

Red blood cells (106/mm3)

8.40 ± 0.19

8.64 ± 0.16

0.083

7.4–11.1

5.8–10.5

Hematocrit (%)

38.66 ± 0.37

38.4 ± 0.80

0.564

34.3–51.3

28.3–68.3

Hemoglobin (g/dL)

13.83 ± 0.15

13.6 ± 0.81

0.773

11.5–15.9

10.1–18.4

MCV

46.03 ± 0.45

45.9 ± 0.43

0.564

46.8–48.0

47.0–51.0

MCH

16.57 ± 0.40

16.75 ± 0.68

0.885

14.1–16.9

14.6–18.5

MCHC

35.53 ± 0.83

36.37 ± 0.85

0.061

30.5–35.4

32.4–37.2

Platelet (103/mm3)

849 ± 12.72

730 ± 36.42

0.563

635–1118

179–1025

  1. EE ethanolic extract, FA fraction of alkaloids, WCG water control group, DCG DMSO control group (99% water + 1% DMSO), RV reference value, LABC Laboratory Animal Breeding Center, CPqRR René Rachou Research Center.
  2. *p value was obtained by Student's T-test, comparing EE versus WCG, or FA versus DCG.
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